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1

Neutralization of membrane TNF, but not soluble TNF, is crucial for the treatment of experimental colitis

Clémentine Perrier, Gert de Hertogh, Jonathan Cremer, Severine Vermeire, Paul Rutgeerts, Gert Van Assche, David E. Szymkowski, Jan L. Ceuppens

Journal:

Inflammatory Bowel Diseases

Year:

2012

Language:

english

File:

PDF, 2.33 MB

english, 2012

2

The TNF superfamily in 2009: new pathways, new indications, and new drugs

Malú G. Tansey, David E. Szymkowski

Journal:

Drug Discovery Today

Year:

2009

Language:

english

File:

PDF, 319 KB

english, 2009

3

Too many targets, not enough target validation

David E. Szymkowski

Journal:

Drug Discovery Today

Year:

2001

Language:

english

File:

PDF, 25 KB

english, 2001

4

Antisense Drug Technology: Principles, Strategies, and Applications

David E Szymkowski

Journal:

Drug Discovery Today

Year:

2002

Language:

english

File:

PDF, 49 KB

english, 2002

5

Chemical genomics versus orthodox drug development

David E. Szymkowski

Journal:

Drug Discovery Today

Year:

2003

Language:

english

File:

PDF, 37 KB

english, 2003

6

Rational optimization of proteins as drugs: a new era of ‘medicinal biology’

David E Szymkowski

Journal:

Drug Discovery Today

Year:

2004

Language:

english

File:

PDF, 42 KB

english, 2004

7

Timely lessons for target-based discovery of anti-inflammatory drugs

David E. Szymkowski

Journal:

Drug Discovery Today

Year:

2005

Language:

english

File:

PDF, 88 KB

english, 2005

8

Developing antisense oligonucleotides from the laboratory to clinical trials

David E. Szymkowski

Journal:

Drug Discovery Today

Year:

1996

Language:

english

File:

PDF, 1.49 MB

english, 1996

9

Book review

David E Szymkowski

Journal:

Drug Discovery Today

Year:

1998

Language:

english

File:

PDF, 75 KB

english, 1998

10

Target validation joins the pharma fold

David E. Szymkowski

Journal:

Year:

2003

Language:

english

File:

PDF, 44 KB

english, 2003

11

MUC17, a Novel Membrane-Tethered Mucin

James R. Gum Jr., Suzanne C. Crawley, James W. Hicks, David E. Szymkowski, Young S. Kim

Journal:

Biochemical and Biophysical Research Communications

Year:

2002

Language:

english

File:

PDF, 444 KB

english, 2002

12

Electron Microscopy of DNA Excision Repair Patches Produced by Human Cell Extracts

David E. Szymkowski, M.A.Nasser Hajibagheri, Richard D. Wood

Journal:

Journal of Molecular Biology

Year:

1993

File:

PDF, 1.03 MB

1993

13

Suppression of mast cell degranulation through a dual-targeting tandem IgE–IgG Fc domain biologic engineered to bind with high affinity to FcγRIIb

Saso Cemerski, Seung Y. Chu, Gregory L. Moore, Umesh S. Muchhal, John R. Desjarlais, David E. Szymkowski

Journal:

Immunology Letters

Year:

2012

Language:

english

File:

PDF, 1.35 MB

english, 2012

14

Soluble TNF, but not membrane TNF, is critical in LPS-induced hepatitis

Maria L. Olleros, Dominique Vesin, Agathe L. Fotio, Marie-Laure Santiago-Raber, Sébastien Tauzin, David E. Szymkowski, Irene Garcia

Journal:

Journal of Hepatology

Year:

2010

Language:

english

File:

PDF, 1.81 MB

english, 2010

15

Inhibition of B cell receptor-mediated activation of primary human B cells by coengagement of CD19 and FcγRIIb with Fc-engineered antibodies

Seung Y. Chu, Igor Vostiar, Sher Karki, Gregory L. Moore, Greg A. Lazar, Erik Pong, Patrick F. Joyce, David E. Szymkowski, John R. Desjarlais

Journal:

Molecular Immunology

Year:

2008

Language:

english

File:

PDF, 558 KB

english, 2008

16

Reduction of total IgE by targeted coengagement of IgE B-cell receptor and FcγRIIb with Fc-engineered antibody

Chu, Seung Y., Horton, Holly M., Pong, Erik, Leung, Irene W.L., Chen, Hsing, Nguyen, Duc-Hanh, Bautista, Cristina, Muchhal, Umesh S., Bernett, Matthew J., Moore, Gregory L., Szymkowski, David E., Desj

Journal:

Journal of Allergy and Clinical Immunology

Year:

2012

Language:

english

File:

PDF, 861 KB

english, 2012

17

Central but not peripheral administration of XPro1595 is therapeutic following moderate spinal cord injury in mice

Novrup, Hans, Bracchi-ricard, Valerie, Ellman, Dite, Ricard, Jerome, Jain, Anajana, Lyck, Lise, Szymkowski, David, Lambertsen, Kate, Bethea, John R.

Journal:

Journal of Neuroimmunology

Year:

2014

Language:

english

File:

PDF, 126 KB

english, 2014

18

Inhibition of soluble TNF protects mice against brain inflammation and demyelination in a cuprizone model for multiple sclerosis

Karamita, Maria, Barnum, Chris, Tesi, Ray, Szymkowski, David, Tansey, Malu, Probert, Lesley

Journal:

Journal of Neuroimmunology

Year:

2014

Language:

english

File:

PDF, 45 KB

english, 2014

19

Suppression of innate and adaptive B cell activation pathways by antibody coengagement of FcγRIIb and CD19

Szili, Dániel, Cserhalmi, Marcell, Bankó, Zsuzsanna, Nagy, György, Szymkowski, David E, Sármay, Gabriella

Journal:

Year:

2014

Language:

english

File:

PDF, 701 KB

english, 2014

20

Central but not systemic administration of XPro1595 is therapeutic following moderate spinal cord injury in mice

Novrup, Hans G, Bracchi-Ricard, Valerie, Ellman, Ditte G, Ricard, Jerome, Jain, Anjana, Runko, Erik, Lyck, Lise, Yli-Karjanmaa, Minna, Szymkowski, David E, Pearse, Damien D, Lambertsen, Kate L, Bethea

Journal:

Journal of Neuroinflammation

Year:

2014

Language:

english

File:

PDF, 2.71 MB

english, 2014

21

Systemically administered anti-TNF therapy ameliorates functional outcomes after focal cerebral ischemia

Clausen, Bettina, Degn, Matilda, Martin, Nellie, Couch, Yvonne, Karimi, Leena, Ormhøj, Maria, Mortensen, Maria-Louise, Gredal, Hanne, Gardiner, Chris, Sargent, Ian I L, Szymkowski, David E, Petit, Gér

Journal:

Journal of Neuroinflammation

Year:

2014

Language:

english

File:

PDF, 1.68 MB

english, 2014

22

Dominant‐Negative Tumor Necrosis Factor Protects from Mycobacterium bovis Bacillus Calmette‐Guérin (BCG) and Endotoxin‐Induced Liver Injury without Compromising Host Immunity to BCG and Mycobacterium tuberculosis

Olleros, Maria L., Vesin, Dominique, Lambou, Agathe F., Janssens, Jean‐Paul, Ryffel, Bernhard, Rose, Stéphanie, Frémond, Cécile, Quesniaux, Valérie F., Szymkowski, David E., Garcia, Irene

Journal:

The Journal of Infectious Diseases

Year:

2009

Language:

english

File:

PDF, 881 KB

english, 2009

23

A Dictyostelium discoideum cDNA coding for a protein with homology to the rat ribosomal protein L7

Szymkowski, David E., Kelly, Brooks, Deering, Reginald A.

Journal:

Nucleic Acids Research

Year:

1989

Language:

english

File:

PDF, 69 KB

english, 1989

24

Allergic Lung Inflammation Is Mediated by Soluble Tumor Necrosis Factor (TNF) and Attenuated by Dominant-Negative TNF Biologics

Maillet, Isabelle, Schnyder-Candrian, Silvia, Couillin, Isabelle, Quesniaux, Valerie F. J., Erard, Francois, Moser, René, Fleury, Sébastien, Kanda, Akira, Dombrowicz, David, Szymkowski, David E., Ryff

Journal:

American Journal of Respiratory Cell and Molecular Biology

Year:

2011

Language:

english

File:

PDF, 1.23 MB

english, 2011

25

An Intrastrand d(GpG) Platinum Crosslink in Duplex M13 DNA is Refractory to Repair by Human Cell Extracts

David E. Szymkowski, Kevin Yarema, John M. Essigmann, Stephen J. Lippard and Richard D. Wood

Journal:

Proceedings of the National Academy of Sciences

Year:

1992

Language:

english

File:

PDF, 1.19 MB

english, 1992

26

Harnessing Fc receptor biology in the design of therapeutic antibodies

Sondermann, Peter, Szymkowski, David E

Journal:

Current Opinion in Immunology

Year:

2016

Language:

english

File:

PDF, 752 KB

english, 2016

27

Identification and characterization of a Dictyostelium discoideum ribosomal protein gene

Szymkowski, David E., Deering, Reginald A.

Journal:

Nucleic Acids Research

Year:

1990

Language:

english

File:

PDF, 987 KB

english, 1990

28

Repair by Human Cell Extracts of Single (6-4) and Cyclobutane Thymine- Thymine Photoproducts in DNA

David E. Szymkowski, Christopher W. Lawrence and Richard D. Wood

Journal:

Proceedings of the National Academy of Sciences

Year:

1993

Language:

english

File:

PDF, 1.28 MB

english, 1993

29

Evaluation of Performance of Automatic Vehicle Location and TowPlow for Winter Maintenance Operations in Wisconsin

Santiago-Chaparro, Kelvin, Chitturi, Madhav, Szymkowski, Todd, Noyce, David

Journal:

Transportation Research Record Journal of the Transportation Research Board

Year:

2012

Language:

english

File:

PDF, 1.23 MB

english, 2012

30

Virally infected and matured human dendritic cells activate natural killer cells via cooperative activity of plasma membrane-bound TNF and IL-15

Vujanovic, Lazar, Szymkowski, David E, Alber, Sean, Watkins, Simon C, Vujanovic, Nikola L, Butterfield, Lisa H

Year:

2015

Language:

english

File:

PDF, 347 KB

english, 2015

31

Inhibition of TNF reduces mechanical orofacial hyperalgesia induced by Complete Freund’s Adjuvant by a TRPV1-dependent mechanism in mice

Lis, Krzysztof, Grygorowicz, Tomasz, Cudna, Agnieszka, Szymkowski, David E., Bałkowiec-Iskra, Ewa

Journal:

Pharmacological Reports

Year:

2017

Language:

english

File:

PDF, 528 KB

english, 2017

32

Trypanosoma brucei growth control by TNF in mammalian host is independent of the soluble form of the cytokine

Vanwalleghem, Gilles, Morias, Yannick, Beschin, Alain, Szymkowski, David E., Pays, Etienne

Journal:

Scientific Reports

Year:

2017

Language:

english

File:

PDF, 1.26 MB

english, 2017

33

[American Thoracic Society American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado - ()] C21. NEW TARGETS FOR ASTHMA THERAPY - Suppression Of IgE Production By XmAb7195, An Fc-Engineered Antibody That Specifically Coengages Inhibitory Receptor Fc?RIIb With IgE-BCR

Chu, Seung Y., Horton, Holly M., Chen, Hsing, Karki, Sher, Leung, Irene, Szymkowski, David E., Desjarlais, John R.

Year:

2011

Language:

english

File:

PDF, 18 KB

english, 2011

34

A1.84 Switching off B cells by Fc-engineered anti-CD19 antibody (XmAb5871)

Szili, Daniel, Cserhalmi, Marcell, Bankó, Zsuzsanna, Nagy, Gyorgy, Szymkowski, David E, Sármay, Gabriella

Journal:

Annals of the Rheumatic Diseases

Year:

2014

Language:

english

File:

PDF, 52 KB

english, 2014

35

Soluble TNF Mediates the Transition from Pulmonary Inflammation to Fibrosis

Oikonomou, Nikos, Harokopos, Vaggelis, Zalevsky, Jonathan, Valavanis, Christos, Kotanidou, Anastasia, Szymkowski, David E., Kollias, George, Aidinis, Vassilis, Papavasiliou, Nina

Journal:

Year:

2006

Language:

english

File:

PDF, 2.95 MB

english, 2006

36

Therapeutic inhibition of soluble brain TNF promotes remyelination by increasing myelin phagocytosis by microglia

Karamita, Maria, Barnum, Christopher, Möbius, Wiebke, Tansey, Malú G., Szymkowski, David E., Lassmann, Hans, Probert, Lesley

Journal:

Year:

2017

Language:

english

File:

PDF, 1014 KB

english, 2017

37

Topical Administration of a Soluble TNF Inhibitor Reduces Infarct Volume After Focal Cerebral Ischemia in Mice

Yli-Karjanmaa, Minna, Clausen, Bettina Hjelm, Degn, Matilda, Novrup, Hans Gram, Ellman, Ditte Gry, Toft-Jensen, Peter, Szymkowski, David E., Stensballe, Allan, Meyer, Morten, Brambilla, Roberta, Lambe

Journal:

Frontiers in Neuroscience

Year:

2019

Language:

english

File:

PDF, 3.21 MB

english, 2019

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